Journal of Mechanical Engineering Science and Technology (JMEST)
Abstract
The use of bare metal stents over the long term often leads to the re-narrowing of blood vessels, prompting a shift to drug-eluting stents (DES). However, the use of polymers in DES has been known to trigger inflammation and thrombosis in the arteries. As an alternative, polymer-free drug-eluting stents (PF-DES) have emerged as a safer option. In this study, curcumin was selected as the primary coating material for PFDES using the electrophoretic deposition method. The effects of varying curcumin concentrations (125 µg/ml, 250 µg/ml, and 500 µg/ml) were examined to understand their impact on deposition morphology, coating weight, chemical bonding characteristics, and curcumin release using scanning electron microscopy, ultraviolet-visible spectrophotometry, and Fourier transform infrared spectroscopy. The results showed that increasing the amount of curcumin resulted in a heavier and rougher coating, with deposition weights of 573.22 μg/cm², 1198 μg/cm², and 11954 μg/cm², after coated with curcumin concentrations of 125 µg/ml, 250 µg/ml, and 500 µg/ml, respectively. The curcumin release process was comprised of three phases: an initial burst, a slower release, and a second burst, which completed the release over more than 40 days. The efficacy of curcumin as a coating for PF-DES facilitates a controlled and steady release of the drug.
Publisher
Universitas Negeri Malang
First Page
62
Last Page
74
Recommended Citation
Yani, Ameliyana R.S.P.A. and Herliansyah, Muhammad Kusumawan
(2025)
"Characterization of Curcumin as a Coating Material for Polymer-Free Stents inTerms of Morphology and Release,"
Journal of Mechanical Engineering Science and Technology (JMEST): Vol. 9:
No.
1, Article 6.
DOI: 10.17977/um016v9i12025p074
Available at:
https://citeus.um.ac.id/jmest/vol9/iss1/6
Included in
Computational Engineering Commons, Engineering Science and Materials Commons, Materials Science and Engineering Commons, Mechanical Engineering Commons